Cultivating the information literacy of college students is essential for their comprehensive development in higher education institutions. This article first analyzes the meaning of information literacy, then emphasizes the necessity of integrating information literacy into advanced mathematics teaching in colleges. To address this, it proposes several strategies: developing multimedia courseware to enrich teaching resources, stimulating students’ interest in learning, enhancing the information literacy of vocational college mathematics teachers, organizing mathematical modeling competitions, integrating information literacy education into mathematical modeling courses, and emphasizing the cultivation of students’ information ethics. These measures aim to systematically strengthen students’ information literacy, support their holistic growth, and better prepare them for the demands of an information-driven society.